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Just the opposite, specifically with Rustoleum "Professional" enamels. I just finished off a can I've used off and on for 4 - 5 yrs, worked flawlessly right to the bottom of the can. The instructions say nothing about inverting the can and spraying paint out of the tube, just "wipe paint off nozzle". I've done that and it sprays right away next time I pick it up (months later). Aside from that, it is great paint, very durable and perfect for chassis parts.
https://www.homedepot.com/p/Rust-Ole...8838/100114318