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I used it for many years in the race car when we ran street class. The good old purple 115/145 was available then.
For street you won't have to tune any different unless you want. It will stand more spark advance so you might gain some mileage there. It has about 4 cc's per gallon of tetraethyl lead so you may have to open the plug gaps slightly to forestall leading.
On air cooled engines such as mowers and trimmer's etc. with 4 cycle engines, you may encounter sticking valves over time, due to the lead. In the old days, they set the stem clearance wider.
100LL is around $5 a gallon here now.